I often repeat to them something that — not my mentor, but a senior scientist at the NIH — said to me once. We were having lunch together. I was despondent, despondent because nothing had worked. I had been there a year. And this guy said to me, “Look,” he said, “do you know the difference, Bob, between an average scientist and a world class scientist?” I said no. He said, “Here’s what it is.” He said, “For the average scientist, maybe one percent of their experiments work. But for the world class guy, the world beater, it could be as high as one-and-a-half or two percent.” And then that really stuck with me because it’s really true.

The best advice I got from a painter friend of mine when I said, “If you had one thing to say to an aspiring artist like myself, what would you say?” And she said, “Make as many mistakes as you can.”

“What sound does that color make?” Yeah, that was a question of hers in fifth grade. And I was like, “Well, colors don’t have sound.” And eventually, she said, “You know red sounds different than blue.” And I, “Yeah, red sounds angry, blue sounds —” And so she was pushing me into, “Here’s your simile, here’s your metaphor. This is all you’re going to need. Run, my child.”

Run toward the hardest problems. At the time, I didn’t fully understand what that meant.  But over time, I realized this was the best advice I ever received. Hard problems teach you what you're capable of.  Fast forward a bit … 12 years ago, I got a chance to put that lesson to the test. I had the opportunity to become CEO of AMD. AMD had enormous potential, but the company had been through some tough years. Some of my mentors thought taking the job was risky. But for me, this was my dream job. This was what I’d been training for all those years. The opportunity to work at the bleeding edge of technology on problems that really mattered. The first thing we had to figure out was what we wante

It's family, and it's faith, and it's friends. I would tell them that. Don't forget that. In your brilliance, don't turn your back on your friends. Don't think you're entitled to something because you're smarter than the next guy.

This may sound like a cliché, but I’ll put it this way. The proudest thing in my life is that my children came home. The proudest moment of my presidency, domestically, was when I signed a piece of civil rights legislation known as the ADA, doing something for the disabled. A massive piece of civil rights legislation that put disabled people, 50 million of them, into the mainstream, or at least removed legal obstacles to their being in the mainstream.

If you really want to make a difference, whether it’s in helping other people, or whether it’s in fighting for your country, or whether it’s in the political arena, or journalism, or physics, you’ve got to persevere. You’ve got to understand that there are going to be some enormous bumps in the road.

I don't want to be called a senior citizen, I feel like a spring colt. I don't want to be called a has-been, because there's things I want to do in life. But, I've been there and I'd say, "Don't let the bastards get you down." And they don't anymore, I don't talk to them anymore, so they don't get me down. I've got my family, and I've got so many blessings that I don't think I've earned, that I'm a very happy man.

It’s family, and it’s faith, and it’s friends, and it’s not the glamour of the Presidency, or the wonder of going to receive the Nobel Prize. All those are important, of course. But maybe it’s just that I’m 71 years old now. It’s family, and it’s faith, and it’s friends.

Abraham Lincoln truly inspired me. It wasn't just the freeing of the slaves, he kept the Union together. Some people even forget that today. What I think inspired me was the fact that in spite of being the president of the United States he retained a certain down-to-earth quality. He never got to be a big shot, and he cared about people.