When I was this young assistant at the University of Groningen my responsibility was for four beds, or rather the patients in four beds. That was all I had to do. And, one of these patients was a young man, 22 years old, who slowly and miserably died from renal failure. He became blind, he vomited, and it was a miserable death. And I, as a very, very young physician, had to tell his mother, in a black dress and a little white cap like the farmers have, that her only son was going to die. I couldn’t do a damn thing about it. So, I began to think, “If I could just every day remove as much urea as this boy creates, which is about 20 grams, then the boy could live.” Well, he died, but I began to work on that.

A typical day is probably lots of meetings and stuff. But if it’s an idea that we’re developing, what might happen is I might talk to some of the people in the lab, maybe have them come in the office and brainstorm with them, and say, “Well, here’s a problem that we need to solve,” or need to solve better. So just as an example, when I had this idea that we could create better materials, I got about four or five people together with different backgrounds — chemistry, engineering, safety, toxicology — and we started putting chemical structures on the blackboard and say, “Well, this might work,” or “This might not be safe,” and ended up with certain structures that we thought would be good. And then, one of the guys would go out and try to make those structures, and we’d go from there.

The way I often find what I’m going to write next is by writing.

I remember being present when a Jesuit priest in Rome asked Tennessee Williams, “How do you write a play?” and Tennessee said, “Well, I start with a sentence.” Well, I start with a sentence, and that’s how you write a book.