In all this we can only move forward, if we work in a multilateral setting; and that also is another dimension of this – that is recognises the importance of multilateralism. As the citation says, “broadest international co-operation”. We can only win together or lose together, Marika. I think that’s something I have been saying for quite a while and you probably will hear me say more of that, as we go forward.

I will start by stating the obvious. No one here questions whether development is desirable. No one questions the inherent need to save lives and help others by giving. However, I believe that we need to rethink the ways in which we help others. We need to give from the perspective of empowering the recipient, instead of making them dependent on us.

I never wanted to have to choose between tennis and a family. I don't think it's fair. If I were a guy, I wouldn't be writing this because I'd be out there playing and winning while my wife was doing the physical labor of expanding our family.

In Japan, however, I found myself suffering from Post America Depression or PAD. The environment for researchers in Japan was quite different in many ways from that in the U.S. At the medical school, very few scientists showed interest in the basic biology of mouse ES cells, and there was little thought-provoking discussion with my colleagues. Some of my colleagues advised me to work on something more related to medicine. Furthermore, I could not get enough funding and had to change the cages of the numerous mice by myself every week. What was worse, the Nat1 work was being rejected by many journals. I felt lonely and depressed, and I was about to give up my career as a scientist and return to the path of physician.

If you get stuck, get away from your desk. Take a walk, take a bath, go to sleep, make a pie, draw, listen to ­music, meditate, exercise; whatever you do, don’t just stick there scowling at the problem. But don’t make telephone calls or go to a party; if you do, other people’s words will pour in where your lost words should be. Open a gap for them, create a space. Be patient.

Read Becoming a Writer, by Dorothea Brande. Then do what it says, including the tasks you think are impossible. You will particularly hate the advice to write first thing in the morning, but if you can manage it, it might well be the best thing you ever do for yourself. This book is about becoming a writer from the inside out. Many later advice manuals derive from it. You don’t really need any others, though if you want to boost your confidence, “how to” books seldom do any harm.

I used to be a late starter, but now I get up in the dark like a medieval monk, commit unmediated scribble to a notebook, and go back to bed about six, hoping to sleep for another two hours and to wake slowly and in silence. Random noise, voices in other rooms, get me off to a savage, disorderly start, but if I am left in peace to reach for a pen, I feel through my fingertips what sort of day it is.