Spend your time on something meaningful. Not on parties, and not on taking it easy. That’s not good enough. […] When you’re young, you think: Let’s party, do drugs, drink, waste it all, right? But as you get older, you look at what you’ve accomplished. And when you get old, you’ve run out of time. You have to ask yourself: Why am I here? Can I contribute anything to humanity, to society, my work?

Only the disciplined ones are free in life. If you are undisciplined, you are a slave to your moods. You are a slave to your passions.

Do a deep reflection on what exactly went wrong and write it down. Please don't do that lazy analysis where you just blame government, the economy, the markets, fundraising etc. It might have been a contributing factor and you should reflect that but please do that uncomfortably deep and introspective work of figuring out where *YOU* the founder went wrong.

I think fear and fear of the unknown and perceived failure is what holds people back. For me, I am more scared of complacency than having something not work out. I'd rather take a leap of faith and fall than stand on the edge forever.

I’ve done almost 4,000 operations for brain tumors. I’m thinking of what’s going to happen ten or 12 steps before. I’m anticipating what’s going to happen in the operation, and I’m comfortable with where we are.

I remember reading The Making of a Surgeon when I was in probably about the sixth or seventh grade. And that was a book that kind of got me focused, I think, on the career path. And I remember, one thing in there I still remember is that you can always tell you’ve really arrived as a surgeon when the nurses in the hospital ask you to be their physician.