I often thought I was in the wrong business. I was pretty seriously thinking of tossing it in before I shot Shine.

I have generally had few setbacks and few obstacles. I have been very fortunate in that things have been handed to me rather than my going out after them. There are a few roads that I didn’t take that I maybe could have. When I was a graduate student, maybe a second-year graduate student, I worked frequently at the Illinois State Library in Springfield, and one day, the director of that library called me into his office and said, “I have some news to tell you that is still very hush-hush, but I’m resigning from this job. I’m going to the Chicago Historical Society, and I’m going to recommend that you be appointed in my place.

I tried to get funding to shoot this film and couldn’t—nobody wanted to touch it, you know?

my second failure in my career. But that second failure got me interested in knockout mice, mouse technology. So I think failure is important in my career

Well, this meant 16 months' time to do all the work for a doctor in zoology, including writing a thesis, and it meant working 16 or 17 hours every day and no such things as Saturdays or Sundays or vacations or going to the movies or going out with girls. I just... it was a total grind for 16 months. But I made it;

Anyhow, I talked it over with my mother, and she said, “Well, if that’s what you want, go right ahead.” She was a wonderful woman. And so I did.

Well, you know, the genotype. I'll mention something that nobody ever mentions. Let's say you have now a genotype that makes a certain protein. And that protein, and you can see this in every issue of Science practically, that protein is a very complex structure, incredibly complex. Now how that step from a group of amino acids to that polypeptide [happens] is an enormous jump. I think right now everybody leaves it alone because nobody yet has figured out just exactly how to attack this problem.

Unfortunately I have too many projects going. Two of them, fortunately, are already in the editors’ hands. One is this book on the birds of Northern Melanesia I’m doing with Jared Diamond, and that deals with speciation and particular ecology, biogeographic dispersal and all the other questions.

Well, I’ve completely reneged on that one and within a very short time, I think within three or four years.…Well, it has now been shown that it occurs very commonly in fishes, particularly cichlid fishes. So here’s another thing where my intuition was wrong.

No sir. I'm rather dismayed how many days I have to work on my willpower very strongly in order to get out of bed before 8 o'clock.…I write letters, I write manuscripts, in addition to the book that is in press I have two manuscripts that are going to be published some time this or next year, and I have a whole list of manuscripts that I would like to write.