The studios are superreluctant to give final cut. They have so much money riding on these things, so they want a committee to go and rule the roost.

Logistically, technically, shooting at 48 frames per second, working in 3D – those were all huge challenges. The biggest lessons were more logistical – decision making on a day to day level. It was a very complex schedule, always shifting. So, those were huge challenges. Stamina-wise, there were many, many challenges.

There were lots of times, especially in the early days, that were very, very difficult. I think the most difficult experience I had was in 1990 when Oracle had its only loss quarter in history. We’d been in business for 20 years, and after 20 years we lost money one quarter. We had a very difficult time. We had virtually doubled our sales every year for ten years. Nine out of ten years, ten out of eleven years. It was really quite an amazing run. We were the fastest growing company in history

I do think my mother had a lot to do with that. I mean, after all, you know her — it was not near as bad as having your husband die in a car wreck after — he survives World War II. They had a great life planned, and he gets killed in a car wreck, not because of a concussion, but because in a fluke, the tire blows out on his car. He’s thrown out of the car. He lands in a ditch in a field, and the ditch is full of water, and he can’t get out of the ditch before he drowns. There’s — it made it look a little whiny for me to be all bent out of shape about losing an election, and I realized that it was a weird deal. It was 1980. It was Reagan’s election. It was a period not unlike now, widespread resentment over the stagnant economy, the Iran hostage crisis, and I bet I had a hundred people coming to — I’m not exaggerating — coming to me and saying, “God, Bill, I didn’t know you were going to lose. I just voted against you to because I didn’t like some of the things you’d done.” And I remember once — one of the funniest things that ever happened to me. I was driving over to see my mother. I lived in Little Rock, and she lived in Hot Springs 50 miles away, and in the middle of the trip was a little country store owned by a guy who ran the elections in that area and was real smart, so I went in to get a Coke, and started talking to him. And this little boy came up to me in overalls, and he said, “You’re Bill Clinton, aren’t you?” I said, “Yes.” He said, “I helped to beat you. I cost you 11 votes, and it was no accident.” I said, “You did?” He said, “Yeah.” He said, “It was me, my wife, our two boys and their wives, and five of my friends. We just decked you.” I said, “Why’d you do it?” He said, “I had to because you raised my car tax. The car license.” And so we’re standing on the interstate. I said, “Look over there. You remember when I was governor? That highway broke wide open, and even big trucks were off in the ditch, and I had to send the National Guard down here to clean it up, and we had to fix it.” He said, “Yeah, I remember. I don’t care. I still didn’t want to pay it.” So I was laughing at the guy, and I said, “Let me ask you something.” I said, “If I ever ran again, would you vote for me?” He said, “Absolutely.” I said, “You would?” He said, “Sure. We’re even now.” And I went — and there were no cell phones, so I had a dime. I went and put it in the payphone, and I called Hillary, and I said, “You know, I’m not dead yet. We might have to run again.

I was born in Osaka, Japan. It was 45 years ago. My father has a small factory in Osaka, and we lived next to his factory

I strongly feel that this is, that I am able to receive this award because of John Gurdon and also many other researchers in the field. This field has a long history, starting with John Gurdon. So I feel very lucky. I may have played some important role in this long history, but it was not myself who initiated this field. So that’s my feeling right now.

Well actually I was at home. I was doing some housework. So I was very surprised.

Running CiRA with some 250 staff, I have come to spend less time discussing their data with my colleagues and students, and have been absorbed by my duties as the "chief executive officer" of CiRA, including devising strategies to advance both basic and applied research and to obtain sufficient funding. Anxious about the lack of financial resources for the future to allow us to continue hiring research support staffers, I even ran the full Kyoto Marathon in 2012 to raise online donations from the public. It was hard but helped us raise more than 10 million yen.

Working at the hospital, I found that my surgical skills were not as good as I expected. One time it took me two hours to do a surgical operation which could have been completed in 30 minutes by other surgeons. My supervisors were very tough on new residents like me, and I lost confidence in my ability.

In Japan, however, I found myself suffering from Post America Depression or PAD. The environment for researchers in Japan was quite different in many ways from that in the U.S. At the medical school, very few scientists showed interest in the basic biology of mouse ES cells, and there was little thought-provoking discussion with my colleagues. Some of my colleagues advised me to work on something more related to medicine. Furthermore, I could not get enough funding and had to change the cages of the numerous mice by myself every week. What was worse, the Nat1 work was being rejected by many journals. I felt lonely and depressed, and I was about to give up my career as a scientist and return to the path of physician.