I continued the work on dorsal, discovered the recessive phenotype and interpreted the phenotype postulating a gradient determining the dorsoventral axis. At that time, gradients were not widely accepted as mechanisms, in particular biochemists were highly sceptical, however the Tübingen influence made such models attractive to me.

Seeing the size of the challenge, no wonder many are prey to discouragement; or that apocalyptic prophets abound, announcing the failures of the fight against poverty, proclaiming the immediate fall of the democracies, forecasting the futility of peace-making efforts. I do not share this defeatism. I cannot accept to be realistic means to tolerate misery, violence and hate.

Of course, my decision faced plenty of criticism. One of my fellow Japanese CEOs went so far as to call the plan “stupid” – notable, in a country where executives do not generally criticize one another in the press. Clearly, I would have to fight an uphill battle for cultural acceptance. But I was not deterred. A seismic shift demands that we adapt to a new landscape, and a seismic economic shift is exactly what Japan has undergone in recent decades, driven by the forces of globalization and digitization. The only way to compete in this interconnected internet age is to speak the language of the market – and that language is English.

Yeah, and it’s made it considerably more difficult. It’s funny when you look back now, because everybody’s sort of copied those films. They’re so ingrained in the culture now, it’s almost impossible to think there was a point where those things were completely odd and unique.

Run toward the hardest problems. At the time, I didn’t fully understand what that meant.  But over time, I realized this was the best advice I ever received. Hard problems teach you what you're capable of.  Fast forward a bit … 12 years ago, I got a chance to put that lesson to the test. I had the opportunity to become CEO of AMD. AMD had enormous potential, but the company had been through some tough years. Some of my mentors thought taking the job was risky. But for me, this was my dream job. This was what I’d been training for all those years. The opportunity to work at the bleeding edge of technology on problems that really mattered. The first thing we had to figure out was what we wante