In Rakuten's case, adjustment certainly took time. At first, meetings often felt awkward. The first board meeting after the Englishization decision took four hours to complete – double the normal duration. But whenever executives asked if they could say certain things in Japanese, I told them no. I knew that the challenge would pay off – and it has.

No, because I started working on ribosomes when I was a post doc, in 1978, when it would have been impossible, really, to solve it. But, it was just a fundamental problem in biology. And we felt, no matter, anything we do to chip away at the problem would be useful. So it was more that that attracted me. And I think the fact that it was large and kind of difficult to come to grips with, yes, it was attractive. Really what was attractive was that it was a fundamental problem.

So I decided I was going to invest my time. I spent Monday through Thursday at Frito-Lay, commuting from New York to Texas. Then Friday, Saturday and Sunday, I did my regular job in New York. It was an incredible commitment of time but it was an amazing developmental experience. It was challenging, broadening, and helped me reach the position I have today.

From these remarks it will be evident that, allowing only ordinary ability and opportunity, we may explain success mainly by one word and that word is WORK! WORK!! WORK!!! WORK!!!! Not transient and fitful effort, but patient, enduring, honest, unremitting and indefatigable work, into which the whole heart is put, and which, in both temporal and spiritual affairs, is the true miracle worker. Every one may avail himself of this marvellous power, if he will. There is no royal road to perfection.

Arriving in the States, I had the feeling of being thrown into an ocean. The ocean was full of knowledge, culture, and opportunities, and the choice was clear: I could either learn to swim or sink. The culture was foreign, the language was difficult, but my hopes were high. I did not speak or write English fluently, and I did not know much about western culture in general, or American culture in particular.

At the age of 21, as a Moeid, I believed that behind every universal phenomenon there must be beauty and simplicity in its description. This belief remains true today.

The great singer Um Kulthum (actually named Kawkab Elsharq – a superstar of the East) had a major influence on my appreciation of music. On the first Thursday of each month we listened to Um Kulthum's concert – "waslats" (three songs) – for more than three hours. During all of my study years in Egypt, the music of this unique figure gave me a special happiness, and her voice was often in the background while I was studying mathematics, chemistry… etc. After three decades I still have the same feeling and passion for her music.