My wife, my children, my friends, myself. I’m my own strongest critic. I am much tougher on myself than anybody I know, consistently.

I surround myself with brilliant people who are wise and whose advice I can lean on at every possible moment. The Genome Project is a wonderful team effort. It’s not my project, this is a project that involves close to 1,000 scientists at institutions all over the world. The United States is taking a larger role than any other country, but many other countries are participating. In the U.S. we have a large number of genome centers. We have experts in almost every area. I have advisors who are willing to give up their time and energy to making sure we get there responsibly. It is a heavy load of responsibility, but I can share that load with people who are every bit as committed to the future of this endeavor as I am.

Yes, I’m part of the Rolex mentoring programme for the 2023-2024 season, and my mentor, the architect Anne Lacaton, is actually the one who suggested I should do a project here. I explained in my application about how much influence it’s had on me, so she told me we should take advantage of this time together and work on something in my hometown. Her guidance has been so crucial, especially because I have such strong personal ties to the area, she’s been extremely helpful in reminding me of what my role is as an architect.

People refer to the ‘LMB culture’ as the thing, one of the things, that makes it special. It’s an attention to people who are willing to tackle very big problems. I mean problems that are so big that you couldn’t just solve it in a grant. The kind of problem that you could devote your life to. I was very fortunate in having mentors of Fred Sanger and César Milstein who exercised a kind of very benign mentorship but encouraged us to think big.

Our culture lionizes entrepreneurs who navigate daring switchbacks in their career. Steve Jobs was admired not just for Apple, but also his detour to found Pixar. Elon Musk is revered for helming Tesla AND SpaceX. But don't be distracted by other people's winding paths. I believe you should celebrate your single-mindedness, and stick to your own overarching idea — for as long as it holds your own fascination. In my experience, that could last your entire career.

This is going to sound a little strange, but my trainer started recommending that I add moringa leaf powder to my tea. That’s actually added a rich antioxidant, anti inflammatory and a little bit more substance such that drinking tea now feels a little bit like a snack and is super healthy.

The challenge of a big, over-arching vision is that it's hard to know where to start. And your biggest opportunity will change from year to year. Technology changes. Competition changes. You change. My advice: Just start. Find a single unmet need that nudges the world closer to where you believe it's going. And if you hit a dead end, pivot.