The world ‘ageing’ itself is an issue: we do not know what it means.

Well, you know, the genotype. I'll mention something that nobody ever mentions. Let's say you have now a genotype that makes a certain protein. And that protein, and you can see this in every issue of Science practically, that protein is a very complex structure, incredibly complex. Now how that step from a group of amino acids to that polypeptide [happens] is an enormous jump. I think right now everybody leaves it alone because nobody yet has figured out just exactly how to attack this problem.

I'd need a great business partner. I'm glad we're talking about it because it's been a great frustration in my life. I can't seem to find the right person to help me do that.

We still don’t understand the way a protein folds the way it does. I mean it’s an amazing thing.

Did I have a dream job? I’m not sure. I remember making a little, two-page magazine like kids do, but I never intended to do that as a job, I just thought it was a way having a parallel life to school, doing something different. But I never had that in mind.

Well, I don’t agree with Sartre. I like others.

I have never made any money from my films but I have won prizes and recognition. I have been on the margins forever. They all came to see me receive the award - there was Tom Hanks, Steven Spielberg and Richard Gere and so on. I was imagining what they would all be worth in money terms. You see I was never bankable, I could not bring any money ever to the table. I like the friendships and, yes, the admiration but I don’t want to make a big fuss about it. I will go on working as long as I am able!

I would like to be remembered as a film-maker [who] enjoyed life, including pain. This is such a terrible world, but I keep the idea that every day should be interesting. What happens in my days – working, meeting people, listening – convinces me that it’s worth being alive.

I come from the generation who were taught never to throw things out. I like the idea of hanging on to things and repairing items rather than discarding them. It’s not a question of money, more to do with guarding resources and not being wasteful. My children laugh at me when I sit darning a pair of socks.

I was curious. Curiosity is a good thing. And I was curious about different people. And, as I said, I waited until something was strong enough to disturb me or inspire me to make a film.