Do a deep reflection on what exactly went wrong and write it down. Please don't do that lazy analysis where you just blame government, the economy, the markets, fundraising etc. It might have been a contributing factor and you should reflect that but please do that uncomfortably deep and introspective work of figuring out where *YOU* the founder went wrong.

The advice that I would give is try to find something that you like. Try to devote your energies to being very good at it. Try to achieve excellence. Don’t necessarily have as a goal success or getting prizes or whatever, but just doing very good work. And work hard. Keep working at it. Be patient. Realize that you don’t always see the benefits of what you’re doing, short-term. But in the end, the activities that I do, for example, scientific research, can be extremely rewarding. It’s really a very fascinating career.

Having advanced well beyond what the French call "a certain age," I am often asked to convey to younger people helpful advice and counsel. So I will open these remarks with the best advice I ever received. The advice, which I have several times shared with others, was given to me by my mother-in-law on my wedding day. She had a prescription for a happy, enduring marriage: "It pays," she said, "it pays sometimes to be a little deaf."

Well, I will bring this technology to clinics. I really want to help as many patients as possible. As you may know, I started my career as a surgeon 25 years ago. But it turned out that I am not talented as a surgeon

Generally speaking, envy, resentment, revenge, and self-pity are disastrous modes of thought. Self-pity gets pretty close to paranoia and paranoia is one of the very hardest things to reverse. You do not want to drift into self-pity.

They win the respect, the deserved trust, of the people they deal with, and there is huge pleasure in life to be obtained from getting deserved trust. And so the way to get it is to deliver what you’d want to buy if the circumstances were reversed.

inversion frequently will solve problems which nothing else will solve. And in life, unless you’re more gifted than Einstein, inversion will help you solve problems that you can't solve in other ways.

The highest form that civilization can reach is a seamless web of deserved trust. Not much procedure, just totally reliable people correctly trusting one another. That's the way an operating room works at the Mayo Clinic. If a bunch of lawyers were to introduce a lot of process, the patients would all die. So never forget, when you're a lawyer, that you may be rewarded for selling this stuff, but you don't have to buy it. In your own life, what you want is a seamless web of deserved trust. And if your proposed marriage contract has forty-seven pages, my suggestion is you not enter.

if your proposed marriage contract has forty-seven pages, my suggestion is you not enter.

wisdom acquisition is a moral duty. It’s not something you do just to advance in life. Wisdom acquisition is a moral duty.