What makes you want to keep learning?

The questions of the students are often the source of new research.  They often ask profound questions that I’ve thought about at times and then given up on, so to speak, for a while.  It wouldn’t do me any harm to think about them again and see if I can go any further now.  The students may not be able to see the thing I want to answer, or the subtleties I want to think about, but they remind me of a problem by asking questions in the neighborhood of that problem.  It’s not so easy to remind yourself of these things.

I think a very big curiosity. I’m very curious and I like to understand things and not only science but also other things where I just try to find out why things work or how things work. Science and nature caught my attention as a small child already. I was growing up in a city but we had a garden and I loved the garden and then often on vacation I was at a farm and I loved these animals and plants and so on, so I was attracted very early on and then we had a very good teaching actually at my … I don’t know whether my teachers really had much of a role because I was determined very early, but then I also did music and I did languages and Literature and so on. I have broad interests actually other than science, but this is really true, this curiosity.

I have also benefited from teaching; as I try to explain my views to students with critical and open minds, I find myself continually being challenged to go back and rethink ideas. I now see teaching and research as complementary, mutually reinforcing activities.

I got very interested in so-called “knockout mouse” technology. Knockout mouse is a way to study the function of genes. You know, both human and mouse have approximately 20,000 genes. With knockout mouse technology, we can select one gene out of those 20,000 genes, and completely destroy that one particular gene so that we can understand the function of that particular gene. I got very interested in that technology. It was 1992 or 1993 when I graduated from my Ph.D. school. So I decided to study — I decided to learn about knockout mouse technology. But at that time in Japan, only a few scientists were working on knockout mouse technology. That’s why I decided to move to the States, San Francisco