In terms of this issue of these industrial gases affecting the environment, at the beginning the road was not easy, because we were suggesting that society had to change, that industries had to do something different than they were doing at that time. And of course, initially we did not meet with a good reception to these ideas from industry. And even from the scientific community — even though our ideas were well received in the small group of specialists in what we were doing — it was not necessarily well received by the scientific community at large. So we really had to continue doing as good a science as we could, and at the same time trying to well communicate our conviction that it was something important, something that had to change in the way society was functioning.

More than anything else, I had to combat the barriers, and we tore down those barriers. I just had to set a sail against the wind, those strong winds, to end segregation and racial discrimination, but somehow, in some way, I didn’t let those barriers keep me down.

my second failure in my career. But that second failure got me interested in knockout mice, mouse technology. So I think failure is important in my career

But, of course, we had one problem that the modern mountaineer doesn’t have. That is, this psychological barrier. We really didn’t know whether it was humanly possible to reach the top of Mt. Everest. And even using oxygen as we were, if we did get to the top, we weren’t at all sure whether we wouldn’t drop dead or something of that nature. All the physiologists had warned us that the altitude at the summit of Everest was a very marginal altitude and might be extremely dangerous. So, one had this feeling in your mind all the time that maybe you were pushing things a bit beyond what humans were meant to do and you couldn’t ignore that feeling. But, because of strong motivation, you keep plugging on and you seem to be going okay and nothing seems to be going wrong, so you persist. And we persisted, of course, and ultimately, set foot on the summit.

The questions of the students are often the source of new research.  They often ask profound questions that I’ve thought about at times and then given up on, so to speak, for a while.  It wouldn’t do me any harm to think about them again and see if I can go any further now.  The students may not be able to see the thing I want to answer, or the subtleties I want to think about, but they remind me of a problem by asking questions in the neighborhood of that problem.  It’s not so easy to remind yourself of these things.

It's made me a very happy man ever since.

So I find that teaching and the students keep life going, and I would never accept any position in which somebody has invented a happy solution for me where I don’t have to teach.  Never.

The first principle is that you must not fool yourself—and you are the easiest person to fool. So you have to be very careful about that. After you've not fooled yourself, it's easy not to fool other scientists. You just have to be honest in a conventional way after that.

Nothing happens because there’s not enough real activity and challenge: You’re not in contact with the experimental guys.  You don’t have to think how to answer questions from the students.  Nothing!

one of my diseases, one of my things in life, is that anything that is secret I try to undo. And so the locks to those filing cabinets represented a challenge to me. How the hell to open them? So I worked and worked on them. There are all kinds of stories about how you can feel the numbers and listen to things and so on. That's true; I understand it very well - for old- 19 fashioned safes. But these had a new design so that nothing would be pushing against the wheels while you were trying them, and none of the old methods would work. I read books by locksmiths, which always say in the beginning how they opened the locks when the safe is under water and the woman in it is drowning or some-thing, and the great locksmith opened the safe. And then in the back they tell you how they do it, and they don't tell you anything sensible. It doesn't sound like they could really open safes that way — like guess the combination on the basis of the psychology of the person who owns it! So I always figured they were keeping the method a secret, and like a kind of disease, I kept working on these things until I found out a few things. First, I found out how big a range you need to open the combination, how close you have to be. And then I invented a system by which you could try all the necessary combinations - 8,000, as it turned out, because the woman DROWNING عزه Books are always telling how the great locksmith opens the safe under water when the woman in it is drowning. 20 you could be within two of every number. And then I worked out a scheme by which I could try numbers without altering a number that I had already set, by correctly moving the wheels, so that I could try all the combinations in eight hours. And then finally I discovered (this took me about two years of researching) that it's easy to take the last two numbers of the combination off the safe if the safe is open. If the drawer was pulled out, you could turn the number and see the bolt go up and play around and find out what number it comes back at, and stuff like that. With a little trickery, you can get the combination off. So I used to practice it like a cardsharp practices cards, you know - all the time. Quicker and quicker and more and more unobtrusively I would come in and talk to some guy. I'd sort of lean against his filing cabinet, and you wouldn't even notice I'm doing any-thing. I'm not doing anything— just playing with the dial, that's all, just playing with the dial. But all the time I was taking the two numbers off! And then I would go back to my office and write the two numbers down, the last two numbers of the three. Now, if you have the last two numbers, it takes just a minute to try for the first number; there's only 20 possibilities, and it's open. OK? It takes about three minutes to open a safe if you know the last two numbers. So I got an excellent reputation for safe-cracking.