Never save anything for best.

Don’t answer every question you’re asked.

Now, what did I learn from it? I learned that there were people, mostly in the other party, who believe in free trade but didn’t really believe in doing anything for people who lost jobs. That is, every trade deal produces winners and losers, so this was going to work for us in a lot of ways because the Mexicans had much higher tariffs than we did. And because, if you’re a wealthy country, the jobs trade creates pay above the average wage, and often the jobs that are lost pay below. But it’s always assumed that all those people will be retrained and that there will be incentives to invest within driving distance of where they live to create new jobs. And we lost the Congress in ‘94, and I couldn’t get the money, and there was no interest in it until my last year as president when we passed something called the New Markets Initiative. So if I had it to do again, I’d get the money on the front end, and I’d say, “No, no, no, no. I need more money to help the people who will lose the jobs.” I just assumed, I think probably because I had — the Congress was the majority of our party, and also because the people that were for NAFTA, I couldn’t imagine that they wouldn’t want to help the people that wouldn’t be winners.

That things change.

I cannot pretend I am without fear. But my predominant feeling is one of gratitude. I have loved and been loved; I have been given much and I have given something in return; I have read and traveled and thought and written. I have had an intercourse with the world, the special intercourse of writers and readers. Above all, I have been a sentient being, a thinking animal, on this beautiful planet, and that in itself has been an enormous privilege and adventure.

My generation is on the way out, and each death I have felt as an abruption, a tearing away of part of myself. There will be no one like us when we are gone, but then there is no one like anyone else, ever. When people die, they cannot be replaced. They leave holes that cannot be filled, for it is the fate — the genetic and neural fate — of every human being to be a unique individual, to find his own path, to live his own life, to die his own death.

I feel a sudden clear focus and perspective. There is no time for anything inessential. I must focus on myself, my work and my friends. I shall no longer look at “NewsHour” every night. I shall no longer pay any attention to politics or arguments about global warming. This is not indifference but detachment — I still care deeply about the Middle East, about global warming, about growing inequality, but these are no longer my business; they belong to the future. I rejoice when I meet gifted young people — even the one who biopsied and diagnosed my metastases. I feel the future is in good hands.

I’ve had this concern all the time, but I can only hope that if one writes with appreciation and delicacy and respect, then it’s okay. I have to say that I’ve written a hundred times as much as I’ve published, because if there’s any thought of offense or embarrassment, then I will put the thing quietly away.

On the contrary, I feel intensely alive, and I want and hope in the time that remains to deepen my friendships, to say farewell to those I love, to write more, to travel if I have the strength, to achieve new levels of understanding and insight. This will involve audacity, clarity and plain speaking; trying to straighten my accounts with the world. But there will be time, too, for some fun (and even some silliness, as well).

The first biography I read — I think the first scientific biography — was Madame Curie . And my mother, who was a surgeon, worked at the Marie Curie Hospital. She’d met Marie Curie, who was one of her great heroines. And reading the book, I think, was the first portrait of a scientist and the romance of a scientific life.