The question

Which problem are you still chipping away at?

Originally asked

Lifehacker, to people about their working day, How I Work

Lifehacker repeatedly used this exact closing prompt in its named How I Work questionnaire.

You answer as yourself. Nobody on FLAPSS answers as anybody else.

Shinya Yamanaka

Stem cell biologist; Nobel laureate in Physiology or Medicine, 2012

Recorded said elsewhere, not written here
we can select one gene out of those 20,000 genes, and completely destroy that one particular gene so that we can understand the function of that particular gene. I got very interested in that technology. It was 1992 or 1993 when I graduated from my Ph.D. school. So I decided to study — I decided to learn about knockout mouse technology. But at that time in Japan, only a few scientists were working on knockout mouse technology

Academy of Achievement interviewer, Academy of Achievement interview, 2008 source ↗

Others on this question

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Bill Clinton 42nd President of the United States, 1993–2001
We have all these interesting challenges now. No one knows whether automation and robotics, nanotechnology, will kill more jobs than it creates. If it does, that presents a serious problem. What are we going to do? Have a few of us work to support everybody else, or shorten the workweek for everybody? If so, how do we get from here to there? No one knows yet how we’re going to stop cyber terrorism from wrecking honest discourse in democracy and maybe putting our very lives at risk.
Recorded Academy of Achievement interview source ↗
Desmond Tutu Anglican Archbishop of Cape Town; chair of South Africa’s Truth and Reconciliation Commission; Nobel Peace Prize, 1984
So a great deal has changed, but we in the Truth and Reconciliation Commission said, “Watch it. You can kiss reconciliation and forgiveness goodbye, unless the gap between the rich and the poor — the haves and the have-nots — is narrowed, and narrowed quickly and dramatically.” So yes, we face very, very considerable problems.
Recorded Academy of Achievement interview source ↗
Jocelyn Bell Burnell Radio astronomer; discoverer of pulsars
They have a lot of extreme physics going on inside them and scientists use them to test theories of relativity on a cosmic scale. Einstein’s theories are checking out pretty well so far.
Recorded Louise Walsh, University of Cambridge 'Journeys of Discovery' interview series, 1 January 2020 source ↗
Mario Molina Atmospheric chemist; Nobel laureate in Chemistry, 1995
I certainly want to continue trying to understand how the global environment functions. The earth as a system is a very complicated one. And to understand it, we need very many disciplines, very many different scientists working together. I want to continue working with my specialty, which is chemistry, with the atmosphere. There is still much to learn about chemical reactions that occur out there in the air, in the atmosphere. So one of my projects now is to really learn more about this pollution that occurs in cities and that is spreading more through the globe. To learn it in enough detail so we can better tackle it, we can better come up with new ways of using energy, for example, that are not so damaging to the environment.
Recorded Academy of Achievement interview, Sun Valley, Idaho, 29 June 1996 source ↗

More from Shinya Yamanaka

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Question What is one of the best investments you have made — of money, time, or energy? Money & investment
However, it was very natural that a failed surgeon with little experience in molecular biology had a hard time finding a position. A turning point came when I got a fax from Thomas Innerarity at the Gladstone Institute of Cardiovascular Diseases in San Francisco. After a short telephone conversation, Tom was brave enough to give me a postdoctoral position in his lab! Working at Gladstone was one of the best decisions I ever made in my life.
Recorded Laureate-written autobiography for Les Prix Nobel, Nobel Prize Outreach, 1 December 2012 source ↗
Question What counsel would you give your twenty-year-old self — and what should they ignore? Time & hindsight
Well, I will bring this technology to clinics. I really want to help as many patients as possible. As you may know, I started my career as a surgeon 25 years ago. But it turned out that I am not talented as a surgeon
Recorded Adam Smith, Telephone interview recorded shortly after the prize announcement, October 2012, Nobel Prize Outreach, 1 October 2012 source ↗
Question What fills you with the most pride? Identity & self
I strongly feel that this is, that I am able to receive this award because of John Gurdon and also many other researchers in the field. This field has a long history, starting with John Gurdon. So I feel very lucky. I may have played some important role in this long history, but it was not myself who initiated this field. So that’s my feeling right now.
Recorded Adam Smith, Telephone interview recorded shortly after the prize announcement, October 2012, Nobel Prize Outreach, 1 October 2012 source ↗
Question How has a setback or failure set you up for later success? Failure & regret
Working at the hospital, I found that my surgical skills were not as good as I expected. One time it took me two hours to do a surgical operation which could have been completed in 30 minutes by other surgeons. My supervisors were very tough on new residents like me, and I lost confidence in my ability.
Recorded Laureate-written autobiography for Les Prix Nobel, Nobel Prize Outreach, 1 December 2012 source ↗

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