Losing my memory.

To experience the utter powerlessness of locked-in syndrome.

It was reading out loud, but no longer. (I am dyslexic.) I was encouraged by my husband to do a speech for the Royal National Institute of Blind People, which helped me gain my confidence, and the fear disappeared.

To be so cold that I am not able to sleep.

so I sometimes think, why should I talk young women into being a scientist if they then end up being sort of disliked or not accepted by their contemporaries and so it’s a tricky business actually.

Not really. I thought that getting the Nobel Prize was a big interruption in my career, I thought and it was very distracting. It takes a lot of time you know, it just takes time to be honoured, you have to travel and you have to give speeches of things you have, oh it’s so often that you get bored to tears when you hear your own voice. And it’s really taking a lot of your time and there’s no way that during this time you can start something new, I mean you just profit from what you’ve done and there is no time to develop new ideas.

I continued the work on dorsal, discovered the recessive phenotype and interpreted the phenotype postulating a gradient determining the dorsoventral axis. At that time, gradients were not widely accepted as mechanisms, in particular biochemists were highly sceptical, however the Tübingen influence made such models attractive to me.

I immediately loved working with flies. They fascinated me, and followed me around in my dreams.

we know the fish, we know the worm, we know the fly, but we don’t know the links between and we don’t know, when we go back to the branches in evolution, we really don’t know what happened there when they branched and how they divert and what is the major drive for evolution.

I felt at the time that Eric was much more successful than I, he was extremely productive during his time in Zurich, and worked on many very original projects, germ line, cell lineage, sex determination, where not many people could follow him. I also had the impression that I was dependent on him because he had more fly experience and without him I would not have gotten the job. This made our start in Heidelberg a little difficult, until we sorted things out, and from then on we thoroughly enjoyed working in the same lab.